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Lo and A. Craig MacKinlay, "When are contrarian profits due to stock market overreaction," Review of Financial Studies 3 2 , Categories : Classical control theory Economic theories stubs.

Hidden categories: All stub articles. Namespaces Article Talk. Views Read Edit View history. Help Community portal Recent changes Upload file.

Aneuploidy is a drastic divergence from the normal karyotype , as such the potential heterogeneity within these cells makes diagnosis and treatment increasingly difficult.

The increasing importance of genomic instability on cancer progression has been emphasized in recent years.

In regards to the merotelic kinetochore attachments associated with anaphase lag, several genes have been implicated.

Aurora B is a kinase active in late metaphase , and has been shown to function as a checkpoint for the proper attachments of centriole spindles to the chromatid kinetochores.

When Aurora B was partially inhibited by a small molecule drug, Cimini et. Stag2 encodes a cohesin protein responsible for holding sister chromatids together pre-anaphase.

Imaging of cells with Stag2 knock-outs showed increased frequency of lagging anaphase chromatids; subsequent gene correction in human glioblastoma cell lines reduced the occurrence of this genomic instability.

Consequent of this genomic instability , the resulting cancer cells have the potential to diverge in sequence and gain new traits.

This intratumoral heterogeneity creates a tumor mass with different genomic backgrounds as well as unique cellular traits and drug susceptibilities.

Those individuals with higher rates of chromosome instability were associated with worse 5-year survival curves.

While the diploid cell lines remained drug sensitive, the aneuploid lines showed marked increases in mutation rates, drug resistance, and unintended morphological changes to cell phenotypes.

From Wikipedia, the free encyclopedia. Archived from the original on June 29, EMBO Reports. Nature Reviews Genetics.

The Journal of Cell Biology. Journal of Cell Science. Cell Reports. Current Biology. Lung Cancer.

lag deutsch

Craig MacKinlay, "When are contrarian profits due to stock market overreaction," Review of Financial Studies 3 2 , Categories : Classical control theory Economic theories stubs.

Hidden categories: All stub articles. Namespaces Article Talk. Views Read Edit View history. Help Community portal Recent changes Upload file.

Download as PDF Printable version. The merotelic attachments can occur in two ways: centrosome spindle attachments from both poles on the same chromatid kinetochore [5] or the formation of a third centrosome whose microtubule spindles attach to a chromatid kinetochore.

If the migration is significantly delayed the reformation of nuclei will begin to occur without a full complement of chromosomes.

This nuclear envelope formation is also seen for the lone lagging sister chromatid, forming a micronucleus.

The micronucleus has the capacity to persist in the daughter cell but with abnormal replication and maintenance machinery.

This allows for the accumulation of mutations, increasing the potential for future miss-segregation events. This has important implications in the development and persistence of cancers as well as debilitating developmental diseases.

One of the hallmarks of cancer formation and persistence is genomic instability , referring to the increased frequency in sequence mutation, chromosome rearrangement, and aneuploidy.

Aneuploidy is a drastic divergence from the normal karyotype , as such the potential heterogeneity within these cells makes diagnosis and treatment increasingly difficult.

The increasing importance of genomic instability on cancer progression has been emphasized in recent years. In regards to the merotelic kinetochore attachments associated with anaphase lag, several genes have been implicated.

Aurora B is a kinase active in late metaphase , and has been shown to function as a checkpoint for the proper attachments of centriole spindles to the chromatid kinetochores.

When Aurora B was partially inhibited by a small molecule drug, Cimini et. Stag2 encodes a cohesin protein responsible for holding sister chromatids together pre-anaphase.

Imaging of cells with Stag2 knock-outs showed increased frequency of lagging anaphase chromatids; subsequent gene correction in human glioblastoma cell lines reduced the occurrence of this genomic instability.

Consequent of this genomic instability , the resulting cancer cells have the potential to diverge in sequence and gain new traits.

This intratumoral heterogeneity creates a tumor mass with different genomic backgrounds as well as unique cellular traits and drug susceptibilities.

Those individuals with higher rates of chromosome instability were associated with worse 5-year survival curves.

While the diploid cell lines remained drug sensitive, the aneuploid lines showed marked increases in mutation rates, drug resistance, and unintended morphological changes to cell phenotypes.

From Wikipedia, the free encyclopedia. Archived from the original on June 29,

Lag Deutsch Video

Goodbye Lag Compilation Funny Moments (German/Deutsch)

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